HHAL MEDICAL NEWS JUNE
2013
Short Walks After Meals Could Help Control Glucose Levels in Older
Adults
Short bouts of walking after meals may be more effective than a single longer walk in controlling postprandial
hyperglycemia in older adults, according to a study in Diabetes Care.
Ten inactive adults (mean age, 69) with fasting blood glucose levels between 105 and
125 mg/dL completed three separate treadmill programs: walking for 15 minutes after every meal; for 45 minutes at 10:30 a.m.;
and for 45 minutes at 4:30 p.m. Each program
took place over 2 days in a laboratory, with the first day acting as the control and the second as the exercise day.
The 45-minute morning walk and the shorter, thrice daily walks similarly improved 24-hour
glycemic control over the control day, but the shorter walks were more effective than
the longer walks in reducing 3-hour postprandial glucose levels.
The authors call the effects of shorter, frequent walking bouts "substantial," noting that
older adults may feel more comfortable with such a regimen.
Diabetes
Care article
Nuts for a Healthy Weight
A number of previous studies suggest an inverse association
between the frequency of nut consumption and body mass index (BMI) and risk of obesity. Gemma Flores-Mateo, from
the Institut Universitari d'Investigacio en Atencio Primaria Jordi Gol (Spain), and colleagues completed a neta-analysisis
of data resulting from 31 worldwide studies and found not only that most of the studies don't show that patients gain
a significant amount of weight – but that nuts – as part of a healthy, balanced diet – can help to stabilize
insulin and suppress hunger. The study authors conclude that: “diets enriched with nuts did not increase body
weight, body mass index, or waist circumference in controlled clinical trials.”
http://www.reuters.com/article/2013/04/26/us-nuts-idUSBRE93P17K20130426
Seaweeds Are High-Nutrient Food
Seaweeds or marine algae are rich in vitamins – such
as Vitamin C, minerals – including potassium, and nutrients that are important for most of the body’s biochemical
reactions. Researchers from Alagappa University, (India) report that Gelidiella acerosa (red seaweed) and
Sargassum wightii (brown seaweed) are also abundant sources of amino acids valine, methionine, and lysine; as well as the
fatty acid linoleic acid. The study authors submit that: "The results suggest that both the seaweeds have greater nutritional
value and could be used as excellent nutritional supplements.
http://www.nutraingredients-usa.com/Research/Seaweed-could-make-excellent-nutritional-supplements-says-researchers/
Natural Approaches Negate Cardiovascular Risks
Naturopathic medicine is a system of medicine based on the
healing power of nature. Dugald Seely, from the Canadian College of Naturopathic Medicine (Canada), and colleagues enrolled
246 members of the Canadian Union of Postal Workers at 3 study sites (Toronto, Vancouver and Edmonton) for a year-long clinical
trial to determine whether naturopathic lifestyle counseling helped to reduce the risk of cardiovascular disease. Of the total
sample, 207 people completed the study. The control group received enhanced usual care, and the intervention group received
naturopathic care as a supplement to usual care 7 times during the study. Naturopathic doctors provided diet and lifestyle advice for patients to lose between 2.3 and 4.2 kg through a combination of caloric restriction
and regular physical exercise, and dispensed natural health products such as omega-3 fatty acids, soluble fiber, coenzyme
Q10 and other therapies. Outcome measures were defined as change in prevalence of metabolic syndrome
and a reduction in the Framingham 10-year cardiovascular risk score, a score used to estimate a person's risk of heart
disease. The researchers found that at one year, for both primary outcomes the treatment group improved whereas the
control group deteriorated. Specifically, the team observed that the prevalence of metabolic syndrome, a risk factor for heart disease, was reduced by 17% over a year compared with the control group. The study
authors conclude that: “Our findings support the hypothesis that the addition of naturopathic care to enhanced usual
care may reduce the risk of cardiovascular disease among those at high risk.”
http://www.eurekalert.org/pub_releases/2013-04/cmaj-tbn042413.php
Two-Way Tie for Hypoglycemia,
Dementia in Diabetes
(HealthDay
News) – For older adults with diabetes mellitus there appears to be a bidirectional
correlation between hypoglycemia and dementia, according to research published online June 10 inJAMA Internal Medicine.
Kristine Yaffe, MD, from the University of California in San Francisco, and colleagues
prospectively assessed the correlation between hypoglycemia and dementia in a biracial cohort including 783 older adults with
diabetes mellitus (mean age, 74 years).
During a 12-year follow-up period, the researchers found that 7.8% of participants experienced a hypoglycemic
event and 18.9% developed dementia. The risk of dementia was increased significantly for those who experienced vs. those who
did not experience a hypoglycemic event (34.4% vs. 17.6%; multivariate-adjusted hazard ratio, 2.1). Compared with participants
who did not develop dementia, those who developed dementia had a significantly greater risk of having a subsequent hypoglycemic
event (14.2% vs. 6.3%; multivariate-adjusted hazard ratio, 3.1). Similar results were seen after further adjustment for stroke,
hypertension, myocardial infarction, and cognitive change scores.
"In summary, our results provide evidence for a bidirectional association between
severe hypoglycemia and dementia," the authors write. "Hypoglycemia may impair cognitive health, and reduced cognitive
function may increase the risk for a hypoglycemic event that could further compromise cognition, resulting in a detrimental
cycle."
http://archinte.jamanetwork.com/article.aspx?articleid=1696172#Abstract
Coronary
artery calcium score prediction of all cause mortality and cardiovascular events in people with type 2 diabetes: systematic
review and meta-analysis.
CONCLUSION:
In people with type 2 diabetes, a coronary artery calcium score
of ≥ 10 predicts all cause mortality or cardiovascular events, or both, and cardiovascular events alone, with
high sensitivity but low specificity. Clinically, the finding of a coronary artery calcium score of <10 may facilitate
risk stratification by enabling the identification of people at low risk within this high risk population.
http://www.ncbi.nlm.nih.gov/pubmed/23529983
http://www.mdlinx.com/internal-medicine/print-preview.cfm/4554915
Effect of longer term modest
salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials.
CONCLUSIONS:
A modest reduction in salt intake for four or more weeks
causes significant and, from a population viewpoint, important falls in blood pressure in both hypertensive and normotensive
individuals, irrespective of sex and ethnic group. Salt reduction is associated with a small physiological increase in plasma
renin activity, aldosterone, and noradrenaline and no significant change in lipid concentrations. These results support a
reduction in population salt intake, which will lower population blood pressure and thereby reduce cardiovascular disease.
The observed significant association between the reduction in 24 hour urinary sodium and the fall in systolic blood pressure,
indicates that larger reductions in salt intake will lead to larger falls in systolic blood pressure. The current recommendations
to reduce salt intake from 9-12 to 5-6 g/day will have a major effect on blood pressure, but a further reduction to 3 g/day
will have a greater effect and should become the long term target for population salt intake
http://www.ncbi.nlm.nih.gov/pubmed/23558162
http://www.mdlinx.com/internal-medicine/newsl-article.cfm/4580915/ZZ4412CAF671214A3D9CD6491E391891B4/?news_id=2257&newsdt=061813&utm_source=Newsletter&utm_medium=CME-EBM&utm_content=CME-EBM-article&utm_campaign=Article-Section
New PSA Screening Guideline from the American Urological Association
The target range for "routine" prostate-specific antigen screening
has been narrowed to ages 55 to 69.
The American Urological Association (AUA) has published a new guideline on prostate-specific
antigen (PSA) screening. The guideline has five summary recommendations:
· No
screening for men younger than 40.
·
No "routine" screening for men aged 40 to 54 and at average risk;
for those in this age group who are at higher risk (e.g., black men, those with family histories of prostate cancer), individualize
screening decisions.
·
For men aged 55 to 69, engage in shared decision making and proceed based
on the man's values and preferences.
·
No "routine" screening for men older than 70 or men with life expectancy
shorter than 15 years.
·
When screening, consider biennial instead of annual screening.
Efficacy and safety of mirtazapine
in fibromyalgia syndrome patients: a randomized placebo-controlled pilot study
.CONCLUSIONS:Patients with FMS taking mirtazapine exhibited
within-group significant improvement in most of the measured outcomes. Between-group analysis was predictably compromised
by the small sample size. Mirtazapine was well tolerated. Further study with a larger sample size is likely to be useful.
http://www.ncbi.nlm.nih.gov/pubmed/23737510
Severe Sleep Apnea Associated with Higher Risk for Sudden Cardiac
Death
Sleep apnea severity is an independent and significant predictor of sudden cardiac death (SCD), according
to a study in the Journal
of the American College of Cardiology.
Researchers recruited some 11,000 consecutive patients undergoing first-time polysomnography
studies and followed them for an average of 5 years to document incidents of resuscitated or fatal SCD. Over the course of
the study, the annual rate of SCD was 0.27%.
In
multivariable analysis, having a lowest nocturnal oxygen saturation of less than 78% was associated with an increased risk
for SCD (hazard ratio, 1.81). An apnea-hypopnea index above 20 events per hour was also associated with an increased risk.
The authors speculate that the repetitive oxygen desaturations associated with sleep
apnea may cause ventricular ectopy and dysrhythmias; they also observe that these patients show an increase in nighttime coagulability.
Journal
of the American College of Cardiology online-first page
Restless Legs Syndrome Seems an Independent Predictor of Mortality
in Men
Relatively healthy men with restless legs syndrome have nearly twice the risk for death as those without
RLS, according to a prospective study in Neurology.
Over 18,000 male health professionals in the U.S. answered questions about RLS symptoms
and then were followed for roughly 8 years. Four percent had RLS at baseline (symptoms at least five times monthly). Overall,
15% died during follow-up.
After adjustment
for confounders including age and lifestyle risk factors, men with RLS had a 30% increased likelihood of death. In a subgroup
of men without major chronic conditions such as cancer and cardiovascular disease, RLS increased risk nearly twofold. The
increase in mortality was primarily attributed to deaths from respiratory illnesses; blood diseases; and endocrine, metabolic,
and immunity disorders.
The authors
speculate that "the nocturnal blood pressure variations associated with RLS could be among potential underlying mechanisms
for the observed association between RLS and mortality."
Neurology article
Eating Peppers and Tomatoes
May Reduce Parkinson's Risk
New research suggests that eating nicotine-containing foods
from the Solanaceae family, such as peppers and tomatoes, may reduce the risk of developing Parkinson's disease. Dr Susan
Searles Nielsen and colleagues from the University of Washington in Seattle questioned 490 patients newly diagnosed with Parkinson's
and 644 individuals without neurological conditions about their lifetime diet. Participants were also questioned about tobacco
use as previous research has suggested that cigarette smoking and other forms of tobacco (also a plant of the Solanaceae family),
may reduce the risk of developing the disease. Results showed that Parkinson’s disease was inversely associated with
consumption of fruit and vegetables from the Solanaceae family, especially peppers. Consumption of other vegetables had no
impact on Parkinson’s risk. The apparent protection from Parkinson's occurred mainly in men and women with little
or no prior use of tobacco, which contains much more nicotine than the foods studied. "Our study is the first to investigate
dietary nicotine and risk of developing Parkinson's disease," said Dr Searles Nielsen. "Similar to the many
studies that indicate tobacco use might reduce risk of Parkinson's, our findings also suggest a protective effect from
nicotine, or perhaps a similar but less toxic chemical in peppers and tobacco."
http://www.eurekalert.org/pub_releases/2013-05/w-cep050713.php
Long Sleep Duration Linked to Colorectal Cancer
Researchers have found a significant link between long sleep
duration and colorectal cancer, particularly among people who snore or who are overweight. Xuehong Zhang, MD, ScD, instructor
in the Department of Medicine at Harvard Medical School and associate epidemiologist at Brigham and Women's Hospital in
Boston and colleagues analyzed data from more than 100,000 men and women taking part in two prospective cohort studies. Results
showed that people who were overweight or who were regular snorers and who reported sleeping 9-hours or more per day had approximately
a 1.4 to 2-fold increased risk of developing colorectal cancer compared to overweight or regular snorers who slept for 7-hours
each day. The authors believe that the association between long sleep duration and incident colorectal cancer may be explained
by obstructive sleep apnea (OSA), as intermittent hypoxemia, similar to that which occurs in OSA, has been shown to promote
tumor growth in animal models. "Future studies should focus on different populations and evaluate to see whether sleep
duration and sleep quality is a novel risk factor for colorectal cancer and to understand the mechanisms behind this association,"
concluded Zhang.
http://www.eurekalert.org/pub_releases/2013-04/aaos-sda043013.php
Scientists Unveil Potential Treatment for Gray Hair and
Skin Condition Vitiligo
Researchers have announced that a treatment for gray hair may well be on the horizon. A team of European
researchers have discovered that gray hair occurs when there is massive oxidative stress in the hair follicle caused by a
build-up of hydrogen peroxide, which causes the hair to bleach itself from the inside out. The
researchers then went out to discover that the accumulation of hydrogen peroxide can be treated with a topical compound containing
a UVB-activated pseudocatalase. Furthermore, the remedy was also used to successfully treat the skin condition vitiligo.
Study author Karin U. Schallreuter, M.D., from the Institute for Pigmentary Disorders in association with E.M. Arndt University
of Greifswald, Germany and the Centre for Skin Sciences, School of Life Sciences at the University of Bradford, United Kingdom,
said: "To date, it is beyond any doubt that the sudden loss of the inherited skin and localized hair color can affect
those individuals in many fundamental ways. The improvement of quality of life after total and even partial successful repigmentation
has been documented."
http://www.eurekalert.org/pub_releases/2013-05/foas-gha050313.php
Think Zinc
Harvard School of Public Health (Massachusetts, USA) researchers
investigated the intake of zinc in relation to risk of type-2 diabetes in American women.
The team assessed data collected on participants in the Nurses’ Health Study, comprised of 82,297 women, ages 33
to 60 years at the study’s start. The researchers found that those women with the highest average daily intake of zinc
were 10% less likely to develop type-2 diabetes. Further, those women with the highest average total intakes slashed their
risk by 8%. Perhaps most importantly, the researchers showed that an increased intake of zinc was associated with a
28% reduction in type-2 diabetes.
Zinc is a plentiful trace element in the body, and it mediates many physiological functions. The US guidelines
recommend that women ages 19-50 years consume 8 mg of zinc daily; men ages 19-50 years, 11 mg. Shiitake and crimini
mushrooms, spinach, and pumpkin seeds are foods rich in zinc.
Soy and Tomato Combo Best
For Prostate Cancer Prevention
New research suggests that men could help to protect themselves from prostate cancer by eating a combination
of tomatoes and soy foods. John Erdman, a professor of food science and nutrition at the University of Illinois, and colleagues
studied the effect of diet on mice genetically engineered to develop an aggressive form of prostate cancer. Between
the age of 4 and 18-weeks old the mice were fed 1 of 4 diets: 10% whole tomato powder; 2% soy germ; 10% whole tomato powder
and 2% soy germ; or a control diet containing neither tomato nor soy. Results showed that only 45% of mice fed a combination
of tomato and soy had developed prostate cancer by the end of the study, whereas 66% of mice who received tomato or soy developed
the disease. In contrast, 100% of mice in the control group developed prostate cancer. "Eating tomato, soy, and the combination
all significantly reduced prostate cancer incidence. But the combination gave us the best results,” said Professor Erdman.
Study co-author Krystle Zuniga added: "The results of the mouse study suggest that 3 to 4 servings of tomato products
per week and 1 to 2 servings of soy foods daily could protect against prostate cancer." The researchers recommend eating
whole tomatoes and drinking soy milk instead of taking lycopene and soy isoflavones supplements.
http://www.eurekalert.org/pub_releases/2013-05/uoic-sat050813.php
Pine Bark Extract Improves Metabolic Disease Risk Factors
Study results have shown that taking a
daily dose of the pine bark extract pycnogenol may help
to treat or prevent metabolic syndrome, a condition that is linked to type 2 diabetes and cardiovascular disease. Researchers
administered 150 mg/day of the extract to 64 subjects (range 45-55 years) presenting with all 5 risk factors of metabolic
syndrome for 6-months. Another group of 66 matched participants served as controls. Results showed that supplementation with
the pine bark extract was associated with a reduction in waist circumference, triglyceride levels, fasting blood glucose,
and blood pressure, and an increase in HDL cholesterol levels. The authors concluded that the results suggest that the
extract may help to improve health risk factors in people with metabolic syndrome.
http://www.nutraingredients.com/Research/Pine-bark-extract-shows-benefits-against-metabolic-syndrome-Human-data
Fish Oil May Lessen Effects of Junk Food on Brain
A review of 185 research papers concerned with the effects of fish oils suggests that they may help to minimize some
of the deleterious effects that junk food has on the brain. Dr Lucy Pickavance from the University of Liverpool’s Institute
of Ageing and Chronic Disease (UK) and colleagues were analyzing the data in order to determine whether fish oils could aid
weight loss. Results showed that fish oils appeared to be able to stop refined sugars and saturated fats from interfering
with the brain’s ability to control food intake. "Excessive intake of certain macronutrients, the refined sugars
and saturated fats found in junk food, can lead to weight gain, disrupt metabolism and even affect mental processing,”
said Dr Pickavance. "These changes can be seen in the brain's structure, including its ability to generate new nerve
cells, potentially linking obesity to neurodegenerative diseases. Research, however, has suggested that omega-3 fish oils
can reverse or even prevent these effects.” Dr Pickavance concluded that although fish oils don't appear to have
a direct impact on weight loss, they may mitigate the detrimental effects of some of the processes in the brain that are triggered
by eating a high-fat diet
http://www.eurekalert.org/pub_releases/2013-05/uol-fom051413.php
Higher Intake of Marine Omega-3 Fatty Acids Linked to Lower Breast
Cancer Risk
High intake of marine omega-3 polyunsaturated fatty acids, but not other types
of omega-3s, is associated with reduced risk for breast cancer, according to a BMJ meta-analysis.
Researchers examined data from 21 prospective studies comprising nearly 900,000 participants and 2100 cases of
breast cancer. They found that the highest level of intake of marine omega-3s was associated with a significant 14% reduction
in breast cancer risk, relative to the lowest intake. In addition, risk dropped by 5% with each 1 g/day increase in consumption.
There was no association between breast cancer risk and
intake of fish, alpha linoleic acid (a plant-based omega-3), or overall omega-3s.
The researchers note that adjustment for body-mass index
"greatly attenuated" the protective effect of marine omega-3s. Nonetheless, they call the risk reduction "biologically
plausible," perhaps through an effect on molecules involved in cell growth and differentiation.
BMJ article
Eating Walnuts Reduces Cardiovascular Risk
It has been known for some time that eating walnuts can help to lower cholesterol levels, however new research
suggests that they may also convey other cardiovascular benefits. Penny Kris-Etherton, Distinguished Professor of Nutrition
at Penn State, and colleagues gave 15 participants with elevated blood cholesterol 1 of 4 treatments: 85 g of whole walnuts,
6 g of skin, 34 g of defatted nutmeat, or 51 g of walnut oil. The researchers evaluated biochemical and physiological responses
in the participants before the treatments were administered and again 30-minutes, 1-hour, 2 hours, 4-hours, and 6-hours after
administering the treatments. The process was then repeated for each of the remaining 3 treatments. Results showed that consumption
of walnut oil helped to reduce cardiovascular risk by preserving the function of endothelial cells, the cells that line blood
vessels. The researchers also found that walnut oil enhanced the ability of HDL cholesterol to remove excess cholesterol from
the body. "Our study showed that the oil found in walnuts can maintain blood vessel function after a meal, which is very
important given that blood vessel integrity is often compromised in individuals with cardiovascular disease," said Claire
Berryman, graduate student in nutritional sciences, at Penn State. "Implications of this finding could mean improved
dietary strategies to fight heart disease." Walnuts and walnut oil are a rich source of alpha-linolenic acid, gamma-tocopherol,
and phytosterols
http://www.eurekalert.org/pub_releases/2013-05/ps-wwa050813.php
Egg consumption and risk of cardiovascular diseases and diabetes: A meta-analysis.
Abstract
OBJECTIVES:
To assess the dose-response relationship between egg consumption and the risk of cardiovascular diseases
(CVD) and diabetes.
METHODS:
We systematically searched MEDLINE database through December 2012. Fixed- or random-effects model was
used to pool the relative risks (RRs) and their 95% confidence intervals (CIs). Subgroup analyses was performed to explore
the potential sources of heterogeneity. Weighted linear regression model was used to estimate the dose-response relationship.
RESULTS:
Fourteen studies involving 320,778 subjects were included.
The pooled RRs of the risk of CVD, CVD for separated diabetes patients, and diabetes for the highest vs lowest egg intake
were 1.19 (95% CI 1.02-1.38), 1.83 (95% CI 1.42-2.37), 1.68 (95% CI 1.41-2.00), respectively. For each 4/week increment in
egg intake, the RRs of the risk for CVD, CVD for separated diabetes patients, diabetes was 1.06 (95% CI 1.03-1.10), 1.40 (95%
CI 1.25-1.57), 1.29 (95% CI 1.21-1.37), respectively. Subgroup analyses showed that population in other western countries
have increased CVD than ones in USA (RR 2.00, 95% CI 1.14 to 3.51 vs 1.13, 95% CI 0.98 to 1.30, P = 0.02 for subgroup
difference).
CONCLUSIONS:
Our study suggests that there is a dose-response positive association between egg consumption and the risk of
CVD and diabetes
http://www.ncbi.nlm.nih.gov/pubmed/23643053
Increases in Red Meat Intake Linked to Heightened Diabetes Risk
Adults who increase their consumption
of red meat over several years significantly elevate their risk for type 2 diabetes, according to a JAMAstudy.
Some 150,000 U.S. health professionals regularly completed food-frequency questionnaires
and reported their diabetes status. During nearly 2 million person-years of follow-up, 7540 were diagnosed with diabetes.
After multivariable adjustment, participants who increased their intake of red meat
(beef, pork, or lamb) by one-half serving daily over a 4-year period had a significant, 48% increase in diabetes risk during
the subsequent 4 years, relative to those whose consumption was stable. Further adjustment for weight gain attenuated the
association, but the risk increase remained significant (30%).
A corresponding decrease in intake, on the other hand, conferred a significant, 14% risk reduction,
although the effect didn't become apparent until after 12 to 16 years.
A commentator points out that the culprit is the saturated fat content of the meat — not the
type of meat.
JAMA
Internal Medicine article
Should Hypertension Treatment Intensify with Age?
In a feasibility study, targeting antihypertensive treatment to 130/80
mm Hg rather than 140/85 mm Hg significantly increased cerebral blood flow in elderly patients.
Hypertension
leads to reduced cerebral blood flow (CBF), which is associated with cognitive decline. However, aggressive blood pressure
(BP) reduction in the elderly may produce cerebral hypoperfusion, resulting in falls and possibly stroke. In a proof-of-concept
study, investigators recruited 37 primary-care patients aged 70 with uncontrolled
clinical hypertension (defined as a systolic BP of >150 mm Hg as averaged from the second and third of 3 sitting measurements)
while taking 1 antihypertensive medication. Patient s were randomized to receive protocol-defined antihypertensive treatment
to a target BP lower than either 130/80 mm Hg (intensive) or 140/85 mm Hg (usual). Magnetic resonance imaging to measure CBF
and 24-hour ambulatory BP monitoring were performed at baseline and after 12 weeks of treatment.
At baseline, mean BP and mean CBF did not differ significantly between the two groups,
and CBF did not correlate with any BP measure (clinical, ambulatory, aortic, systolic, or diastolic). At 12 weeks, mean clinical
BP fell significantly from baseline in both groups; however, the reduction was significantly greater in the intensive group
than in the usual group (26/17 vs. 15/5 mm Hg). Mean CBF did not change significantly from baseline in the usual group but
increased significantly in the intensive-treatment group, regardless of baseline CBF. In both groups, the change in CBF correlated
significantly with change in systolic BP.
Lithium Reduces Suicide Risk in Mood Disorders
Lithium is associated with significantly lower risk for suicide and all-cause
mortality among both patients with unipolar depression and those with bipolar disorder, according to an updated meta-analysis
inBMJ.
The original analysis was published in 2005, and the update
incorporates a total of some 50 trials including 6700 patients. The principal findings were that lithium was significantly
more effective than placebo at reducing the odds of suicide (odds ratio, 0.13) and death from any cause (OR, 0.38) but not
nonfatal self-harm (OR, 0.60; 95% CI, 0.27 to 1.32). A sensitivity analysis found the same results both in unipolar depression
and bipolar disorder.
The authors write that, given the 30-fold increased risk for suicide in these patients, "lithium should continue
to have an important clinical role."
BMJ article
5-Alpha Reductase Inhibitors Not Associated with Increased Risk
for High-Grade Prostate Cancer
Men who take the 5-alpha reductase inhibitors (5-ARIs), finasteride and dutasteride, for lower urinary
tract symptoms are not at increased risk for high-grade prostate tumors, according to a BMJ study. Since 2011, 5-ARI labels have warned of the increased risk for high-grade prostate cancer.
Using Swedish national registries, researchers assessed 5-ARI use among 27,000 men diagnosed
with prostate cancer and 134,000 controls free of prostate cancer. Overall, use of the drugs was associated with a reduced
prostate cancer risk (odds ratio, 0.89), although the difference was only significant for Gleason scores 2-7. There was no
association with higher Gleason scores, even up to 4 years.
The authors conclude: "Treatment with 5-ARI for men with lower urinary tract symptoms due to prostatic
enlargement provides symptom relief and a decreased risk of surgical procedures. With these benefits in mind and the lack
of serious side-effects, the net balance seems favorable for men with lower urinary tract symptoms treated with 5-ARI."
BMJ article
Americans' vitamin D levels are highest in August, lowest in
February, study shows
ScienceDaily,
UC Irvine and Mayo Clinic
researchers have found that vitamin D levels in the U.S. population peak in August and bottom out in February. The essential
vitamin – necessary for healthy bones – is produced in the skin upon exposure to ultraviolet B rays from the sun.
Vitamin D helps bones absorb calcium and can protect against osteoporosis. It's also thought to play a role in seasonal
illnesses, such as the flu. Low levels of vitamin D are believed to impair "innate immunity" i.e., the body's
first line of defense against pathogens. To further study this link, good estimates of the cyclicality of the vitamin are
necessary. Solar exposure – a timely topic since June 21 marks the first day of summer – is the most important
way people acquire vitamin D. But certain foods, including egg yolks and oil–rich fish like mackerel, salmon, sardines
and herring contain the nutrient. In addition, milk and cereal are often enriched with vitamin D. "Even with food fortification,
vitamin D levels in the population show a high level of seasonality due to the influence of sunlight," said Amy Kasahara,
a UC Irvine graduate student in public health and first author on the paper, which appears in the journal PLOS ONE.
http://www.mdlinx.com/rheumatology/news-article.cfm/4690962/#ixzz2Xc2I7WSW
Efficacy of Probenecid in Patients with
Gout
Khanna D et al., Arthritis Care Res (Hoboken) 2012 Oct 64:1431
This
drug lowered the mean serum uric acid level by 30% to 40%.
Exercise Training Two Times Weekly Improves Fitness as Much as More Frequent Exercise in Older Women
Hunter GR et al., Med Sci Sports Exerc 2013 Jul 45:1386
But four times weekly provided the most benefit.
Aerobic exercise and resistance training can mitigate age-related decline in physical
performance, and it seems intuitive that daily exercise is more beneficial than less frequent exercise. However, optimal frequency
of exercise in older adults is unclear. In this randomized trial, investigators examined the effects of three different combined
aerobic and resistance training programs on total energy expenditure and activity-related energy expenditure (AEE) in 72 older
sedentary women (age range, 60–74).
Participants
were randomized to weekly schedules of 1 day of aerobic and 1 day of resistance training (1+1), 2 days of aerobic and 2 days
of resistance training (2+2), or 3 days of aerobic and 3 days of resistance training (3+3). Aerobic training involved 40 minutes
on a treadmill or cycle ergometer at 80% maximum heart rate; during resistance training, participants performed two sets of
10 repetitions of 10 different exercises. At 16 weeks, aerobic fitness, strength, and fat-free mass improved similarly in
all three groups, but total and activity-related energy expenditure increased significantly (by about 300 kcal daily) only
in the 2+2 group. AEE not related to the scheduled exercise sessions increased significantly in the 2+2 group (by 200 kcal
daily), did not change significantly in the 1+1 group, and decreased significantly in the 3+3 group (by 150 kcal daily).
After Minor Stroke, Adding Clopidogrel to Aspirin Reduces Further
Risk in Some
Patients taking clopidogrel in addition to aspirin after minor ischemic stroke
show a lower risk for early recurrence, according to a New England Journal of Medicine study. An editorialist says the results
apply mostly to Chinese patients on the basis of current evidence.
In a multicenter study, researchers randomized some 5200 Chinese patients
within 24 hours after symptoms of minor ischemic stroke or high-risk transient ischemic attack. Half were assigned to 90 days
of clopidogrel, plus aspirin for the first 21 days; the other half received aspirin plus placebo for 90 days.
During the 90 days, stroke occurred in 8.2% of the clopidogrel-plus-aspirin
group, versus 11.7% of the aspirin-alone group. Moderate or severe hemorrhage (the study's primary safety outcome) occurred
in 0.3% of each group.
An editorialist writes that Chinese patients with these symptoms "should be regarded as a medical emergency"
and should be given the clopidogrel-plus-aspirin regimen.
NEJM article
Diabetes Lifestyle Intervention Trial Stopped: Cardiovascular Outcomes
Unchanged
A long-term study of intensive lifestyle intervention to reduce cardiovascular risks in overweight people with type
2 diabetes finds no advantage over usual diabetes care. The results appear in the New England Journal of Medicine.
In a multicenter study conducted in the U.S., researchers
randomized 5145 people (averaging 59 years of age and a BMI of 36) either to a lifestyle-based intervention that sought to
lower calorie intake and increase activity, or to usual care. The primary outcome was a composite of death from cardiovascular
causes, MI, stroke, or hospitalization for angina.
The planned maximum follow-up was almost 14 years, but the study was stopped after a
median of roughly 10 years, when an interim analysis found no difference in the incidence of the primary outcome (1.83 events
per 100 person-years in the intervention group, vs. 1.92 in controls).
NEJM article
Weight Loss Diets Improve Renal Function in Obese
(HealthDay
News) – Low-fat, Mediterranean, and low-carbohydrate diets are similarly effective in improving renal function
in moderately obese people with or without type 2 diabetes, according to a study published online May 20 in Diabetes Care.
Amir Tirosh, MD, PhD, from Brigham and Women's Hospital in Boston,
and colleagues randomly assigned 318 moderately obese subjects (body mass index, 31 kg/m²) with or without type 2 diabetes
to low-fat, Mediterranean, or low-carbohydrate diets for two years and assessed changes in urinary microalbumin and estimated
glomerular filtration rate (eGFR).
The researchers found that all three diets were effective in significantly improving eGFR, ranging from an increase
of 4–5.3%. The improvement was 6.7% for those with diabetes, 4.5% for those without diabetes, 7.1% for those with lower
baseline renal function, and 3.7% for those with better baseline renal function. After adjusting for a number of factors,
only a decrease in fasting insulin and systolic blood pressure were significantly associated with increased eGFR. All three
diets were found to be associated with a similar improvement in the urine microalbumin-to-creatinine ratio.
"In conclusion, we found that dietary interventions
to reduce weight cause progressive improvement in eGFR and marked regression of microalbuminuria regardless of the dietary
approach," Tirosh and colleagues write.
CONCLUSIONS A
low-carbohydrate diet is as safe as Mediterranean or low-fat diets in preserving/improving renal function among moderately
obese participants with or without type 2 diabetes, with baseline serum creatinine <176 μmol/L. Potential improvement
is likely to be mediated by weight loss-induced improvements in insulin sensitivity and blood pressure.
http://care.diabetesjournals.org/content/early/2013/05/14/dc12-1846.abstract
Vegetarian
Dietary Patterns Tied to Lower All-Cause Death
HealthDay News) – Compared with non-vegetarians, vegetarians have reduced all-cause mortality,
according to a study published online June 3 in JAMA Internal Medicine.
Michael J. Orlich, MD, from Loma Linda University in California, and colleagues conducted
a prospective study involving 73,308 Seventh-day Adventist men and women to examine the correlation between vegetarian dietary patterns and all-cause and cause-specific
mortality. Diet was assessed using a quantitative food frequency questionnaire and classified into five patterns.
During a mean follow-up of 5.79 years, the researchers
identified 2,570 deaths, with a mortality rate of 6.05 per 1,000 person-years. In all vegetarians combined vs. non-vegetarians,
the adjusted hazard ratio for all-cause mortality was significantly reduced (0.88). Compared with non-vegetarians, the adjusted
hazard ratios for all-cause mortality were 0.85 for vegans, 0.91 for lacto-ovo-vegetarians, 0.81 for pesco-vegetarians, and
0.92 for semi-vegetarians. Vegetarian diet was significantly correlated with cardiovascular mortality, non-cardiovascular
non-cancer mortality, renal mortality, and endocrine mortality. The correlations were larger and more often significant for
men than women.
"In
conclusion, in a large American cohort, we found that vegetarian dietary patterns were associated with lower mortality,"
the authors write. "The evidence that vegetarian diets, or similar diets with reduced meat consumption, may be associated
with a lower risk of death should be considered carefully by individuals as they make dietary choices and by those offering
dietary guidance.
http://archinte.jamanetwork.com/article.aspx?articleid=1691919#Abstract
Low
Blood Pressure Linked to Brain Atrophy
(HealthDay News) – In patients with arterial disease, having a low baseline diastolic blood pressure is associated with greater brain atrophy, while declining blood pressure is associated with less brain atrophy,
according to a study published online June 10 inJAMA Neurology.
Noting that the association
between blood pressure and brain atrophy has been unclear, Hadassa M. Jochemsen, MD, from the University Medical Center Utrecht
in the Netherlands, and colleagues prospectively examined baseline blood pressure and changes in blood pressure in 663 patients
with manifest arterial disease (coronary artery disease, cerebrovascular disease, peripheral artery disease, or abdominal
aortic aneurysm).
The researchers found that after a mean follow-up of 3.9 years, and after adjusting for possible confounding
factors, lower baseline diastolic blood pressure or mean arterial pressure was associated with greater progression of subcortical
atrophy. In patients with higher baseline blood pressure (diastolic, systolic, or mean arterial), declining blood pressure
over time was associated with less progression of subcortical atrophy compared to that seen in patients whose blood pressure
was rising.
"This could imply that blood pressure lowering is beneficial in patients with higher blood pressure
levels, but caution should be taken with further blood pressure lowering in patients who already have a low diastolic blood
pressure," Jochemsen and colleagues conclude.
Conclusions and Relevance
In patients with manifest arterial disease, low baseline DBP was associated with more progression of subcortical atrophy,
irrespective of the BP course during follow-up. Furthermore, in patients with higher baseline BP, declining BP levels over
time were associated with less progression of subcortical atrophy. This could imply that BP lowering is beneficial in patients
with higher BP levels, but caution should be taken with further BP lowering in patients who already have a low DBP.
http://archneur.jamanetwork.com/article.aspx?articleid=1696623#Abstract
Vegetarians May Have Lower Mortality Risk
Eating a vegetarian diet is associated with a reduced mortality risk, according to a study in JAMA Internal Medicine.
Researchers studied
73,000 Seventh-day Adventists, who were asked about details of their diet at baseline. About 52% were classified as vegetarian,
including some who ate meat or fish occasionally. Over a median follow-up of 6 years, vegetarians had a 12% lower overall
mortality risk than nonvegetarians, after adjustment for confounders. The benefits of a vegetarian diet were more pronounced
in men than in women. Of the subgroups of vegetarians, those who also ate fish had the lowest mortality risk.
A commentator who is vegetarian offers this advice to clinicians: "Our debates
about the superiority of one diet over another have not served the public well. It is time to acknowledge the common features
of diets associated with good clinical outcomes and to focus our attention on helping patients avoid the intense commercial
pressures to eat otherwise."
JAMA
Internal Medicine article
Two FDA Officials Quarrel Over Safety of Angiotensin-Receptor Blockers
Two FDA officials are quarreling in public about their different views on the safety of angiotensin-receptor blockers
(ARBs), the Wall Street
Journal reports.
One official,
Thomas Marciniak, contends that ARBs may increase the risk for cancer. But
Marciniak's boss, Ellis Unger, told the WSJ that Marciniak's
concerns are a "diversion."
In 2010, the
FDA announced it was reviewing the safety of ARBs following a study that raised the possibility that the drugs might cause
a small but significant increase in risk for cancer. One year later, the FDA said it had concluded its review and found
no evidence of increased risk. "We have no reason to tell the public anything new," Unger
told the WSJ.
Marciniak claims that the FDA review was not sufficiently rigorous because it relied
on summary data provided by drug companies. On his own initiative, Marciniak analyzed patient-level data and concluded that
ARBs were associated with a 24% increase in risk for lung cancer.
Adapted with permission from CardioExchange.
Wall
Street Journal story
Temporal sequence of atherosclerosis
This study concluded that at all levels of coronary artery calcium,
coronary heart disease was the most common first cardiovascular disease event and this analysis represents a novel approach
to understanding the temporal sequence of cardiovascular events associated with atherosclerosis. The American Journal of Cardiology
Antioxidants and heart failure risk
The total antioxidant capacity of diet, an estimate reflecting all
antioxidants in diet, was associated with lower risk of heart failure. These results indicate that a healthful diet high in
antioxidants may help prevent heart failure. The American Journal of Medicine
Study: 4 healthy behaviors reduce
risk of death, heart disease
People who ate a Mediterranean-style diet, exercised, maintained
a normal weight and did not smoke reduced their chances of death from all causes by 80% over about eight years, compared with
those who did not adopt the behaviors, according to Johns Hopkins researchers. The report, published in the American Journal
of Epidemiology, was based on data on more than 6,200 men and women. United Press International
Metabolic syndrome and the severity
of kidney stones
In this cross-sectional study of a nationally representative sample
of Japanese patients with kidney stones, the authors discovered a graded association between number of metabolic syndrome
traits and severity of kidney stone disease, suggesting that kidney stone disease should be regarded as a systemic disorder
linked to metabolic syndrome. Dietary instructions and lifestyle guidance might be valuable tools for preventing stone recurrence. American Journal of Kidney Diseases
Breast-feeding and blood pressure
Parous women who breast-feed have significantly lower odds of having
high blood pressure compared with both parous women who do not breast-feed and nulliparous women. American Journal of Obstetrics &
Gynecology
Silent Myocardial Infarction Predictors
Silent myocardial infarctions are more common than previously thought.
In this study, 1 of 4 patients with suspected coronary artery disease had experienced a silent myocardial infarction; the
extent on average is 10% of the left ventricle, and it is more common in diabetics. The American
Journal of Medicine
Cystatin C as predictor for cardiovascular events
Among post-menopausal women with angiographically documented coronary artery
disease in this study, baseline cystatin C level was associated with worse clinical outcomes without accelerated progression
of atherosclerosis. The American
Journal of Cardiology
Hormone therapy doesn't affect women's
cognitive ability later in life
Women aged 50 to 55 who received hormone therapy for an average of seven
years had the same global cognitive functioning 10 years later compared with those who took placebos, a study in JAMA Internal
Medicine showed. The findings remained consistent regardless of whether the treatment was conjugated equine estrogen alone
or in combination with medroxyprogesterone acetate. Family Practice News
Vitamin D and mortality
This study found an inverse association between 25(OH)D and all-cause
and cardiovascular disease mortality in healthy adults with serum 25(OH)D levels ≤21 ng/mL. Clinical trials for the primary
prevention of cardiovascular disease with 25(OH)D supplementation may target healthy adults with serum 25(OH)D levels ≤21
ng/mL to validate these findings.The American Journal of Medicine
Higher diabetes risk seen with increased
red meat intake
An analysis of data from the Nurses' Health Study 1 and 2 and
the Health Professionals Follow-up Study found that people who ate more than a half a serving of red meat daily for four years
had a 48% higher risk of developing type 2 diabetes. However, cutting back on red meat may help reduce the risk, the study
lead author noted in JAMA Internal Medicine. Bloomberg
Stress linked to pain among women
in Swedish study
Swedish researchers followed 1,462 women for several decades and
found that those who had high mental stress levels at the beginning of the study had a greater likelihood of reporting physical
pain and aches that were not linked to particular conditions. The findings appear in the International Journal of General
Medicine. "These symptoms, while not necessarily dangerous, can have a major impact on quality of life and may also ratchet
up health care costs," said Dr. Sarah Samaan, who was not involved in the study. DailyRx.com
Sleep deprivation linked to heart
attack risk among women
Sleeping for less than six hours a night was associated with higher
levels of inflammation in women with heart disease, elevating their risk of heart attack, according to a study in the Journal
of Psychiatric Research. Researchers did not observe a link between sleep deprivation and heart attack risk in men. United Press International
Survey data link healthy behaviors
to better memory
A survey of more than 18,000 adults links healthy behaviors -- such
as a good diet, not smoking and regular exercise -- to better memory, according to research published in the journal International
Psychogeriatrics. Data showed people who engaged in four healthy behaviors were 111% less likely to report memory problems,
while those who engaged in just one healthy behavior were 21% less likely to report memory problems, compared to those who
had no healthy behaviors. Medscape (free registration)
Target systolic blood pressure
In high-risk hypertensive patients, major cardiovascular events are significantly
lower in those with systolic blood pressures <140 mm Hg and <130 mm Hg than in those with levels >140 mm Hg. There
are stroke benefits at levels <120 mm Hg, but they are offset by increased coronary events. Renal function is best protected
in the 130-139 mm Hg range.The American Journal of Medicine
Alzheimer's drugs linked to lower
death, heart attack risk
Alzheimer's disease patients who took cholinesterase inhibitors
to improve cognitive function were 34% less likely to die and experience myocardial infarction than non-users, researchers
found. The risk of myocardial infarction was lowest among those who took the highest doses. The study, based on data from
more than 7,000 patients in Sweden, was published in the European Heart Journal. MedPage Today (free registration)
Higher doses of vitamin D warranted
Two different regimens of vitamin D supplementation resulted in
no change in 25(OH)D levels over 11 weeks during the fall through spring months in a diverse group of healthy adolescents
with baseline vitamin D sufficiency. (Full-text access is time limited.) Journal of Adolescent Health
The Hypothalamus Strongly Influences
Body Aging
Two master molecules influence aging histology in mice.
Zhang G et al. Nature 2013 May 9; 497:211
Gabuzda D and Yankner BA. Nature 2013 May 9; 497:197
Intensive Lifestyle Intervention for Overweight Patients with Diabetes — A Randomized Trial
Gerstein HC., N Engl J Med 2013 Jun 24;
The intervention didn't lower cardiovascular morbidity and mortality, but caveats apply.
Randomized Controlled Trial of Various Doses of Supplemental Vitamin D in Infancy
Abrams SA., JAMA 2013 May 1; 309:1830
For now, 400 IU still seems to be the best daily dose.
Iodine Deficiency During Pregnancy and Adverse Cognitive Effects in Offspring
Stagnaro-Green A and Pearce
EN., Lancet 2013 May 22;
Even mild deficiency in developed countries poses elevated risk.
Hypoglycemia and Cognitive Decline: Which Comes First?
Yaffe K et al., JAMA Intern Med 2013 Jun 10;
Each increases risk for developing the other.
Atorvastatin, Rosuvastatin, and Simvastatin Are Associated with Excess Risk for Diabetes
Huupponen R and Viikari
J., BMJ 2013 May 23; 346:f3156
Using low doses of these drugs might mitigate the risk.
Targeting High-Dose Statins in Patients with Stable Angina
Dorresteijn JAN et al., Circulation 2013 May 14;
A rule based on 13 clinical factors identified patients at low or high risk for adverse vascular events.
Metformin vs. Glipizide for Patients with Diabetes and
Coronary Disease
Hong J et al., Diabetes Care 2013 May 36:1304
Metformin was associated with better cardiovascular outcomes.
Sunscreen Prevents Skin Aging
Using a broad-spectrum sunscreen daily helps to reduce wrinkles and sagging
skin.
Soy Compound Combats Degenerative Brain Disorders
Phosphatidylserine may improve the functioning of genes involved in Parkinson's
disease and Familial Dysautonomia (FD).
Joint Health Supplements May Guard Against Colorectal Cancer
Glucosamine and chondroitin may help to lower a person's risk of colorectal
cancer.
Seaweeds Are High-Nutrient Foods
Red and brown seaweed are rich in vitamins, minerals, amino acids and
fatty acids.
Lab-Grown Brain Cells Hold Promise to Treat Neurological Conditions
Researchers successfully grow a key type of human brain cell in the laboratory,
and successfully transplant it for further maturation in the brains of mice.
Ubiquitous Chemical Raises Risk of Childhood Hypertension
Phthalates may raise the risk of elevated blood pressure in children and
teens.
Diabetes Drug Tackles Neurodegenerative Diseases
A drug that controls type-2 diabetes may help to repair spinal cords affected
by inherited neurodegenerative disease, in a mouse model.
Food for Thought
Consuming a Mediterranean diet, with added extra-virgin olive oil or mixed
nuts, improves the brain power of older men and women.
Vitamins May Curb the Onset of Alzheimer's Disease
High-dose B vitamins help to prevent shrinkage of a specific region of
the brain associated with Alzheimer's Disease.
High-Tech Grapefruit
Nanoparticles derived from natural lipids present in grapefruit may be
deployed as novel drug delivery vehicles.
FATTY ACIDS, LIPIDS & OILS
Seaweeds Are High-Nutrient Foods
Red and brown seaweed are rich in vitamins, minerals, amino acids and
fatty acids.
Omega-3 Compounds Promote Blood Vessel Health
The ethyl ester form of omega-3 fatty acids may improve arterial stiffness,
among obese men and women.
Omega-3s Hold Promise for Breast Cancer
Omega-3 fatty acids and their metabolite products may slow or stop the
proliferation of triple-negative breast cancer cells by as much as 90%
Fish Oil Exerts Beneficial Effects on Heart Rate
With continuing scientific evidence attesting to heart health benefits
of fish oil, a new meta-study attributes the effects to a favorable influence on heart ra
Fish Oil Protects Memory & Reaction Skills
Dietary supplementation of docosahexaenoic acid (DHA) helps to improve
memory and reaction times, among healthy young men and women.
Omega-3s May Protect Against Skin Cancer
Dietary supplementation of omega-3 fatty acids from fish oil may help
to protect against skin cancer.
Omega-3s Inhibit Breast Cancer Progression
A lifelong diet rich in omega-3 fatty acids may help to inhibit growth
of breast cancer tumors by 30%.
Natural Approaches May Help Clear Brain Plaques
Vitamin D3 and omega-3 fatty acids may enhance the immune system's
ability to clear the brain of the amyloid plaques characteristic of Alzheimer’s Disease.
Omega-3s May Postpone Metabolic Disorders
Supplementation with omega-3 fatty acids may postpone the onset of metabolic
disorders and associated declines in cognitive functions.
Omega-3s for Heart Health Affirmed
Review confirms the value of omega-3 fatty acids in reducing the risk
of heart disease.
Poll
Suggests Healthy Lifestyle Choices May Lead To Fewer Memory Complaints
http://mnt.to/l/4dQ9
General Anesthesia
Raises Dementia Risk Among Elderly Patients
http://mnt.to/l/4dR4
Potential
For Blood Test To Diagnose Alzheimer's In Earliest Stage
http://mnt.to/l/4dNM
Reducing
Levels Of Ataxin-1 May Be The Answer In Neurodegenerative Disorders
http://mnt.to/l/4dNB
Chemical
Reaction Identified That Causes Alzheimer's Plaques To Grow Exponentially
http://mnt.to/l/4dNw
Treating
Alzheimer's Disease - New Chemical Approach
http://mnt.to/l/4dN2
Understanding
What Goes Wrong In Alzheimer's Disease - Preventing 'Traffic Jams' In Brain Cells
http://mnt.to/l/4dMx
Meditation, Stretching Ease PTSD Symptoms In Nurses
http://mnt.to/l/4dNn
Developing
Good Habits Is More Important Than Self-Control In Meeting Goals
http://mnt.to/l/4dKX
Discovery Of Possible Key To
Cause Of Cushing Disease
http://mnt.to/l/4dQF
Stimulating The Immune System To Fight Brain Tumors
http://mnt.to/l/4dQ4
Exposure
To Dry-Cleaning Solvent And Degreaser TCE Linked To Increased Risk Of Some Cancers
http://mnt.to/l/4dPB
Randomized
Clinical Trials In Radiation Oncology Clinical Practice Of Great Value
http://mnt.to/l/4dNt
Nanoparticles
That Shape-Shift Flip From Sphere To Net In Response To Tumor Signal
http://mnt.to/l/4dMy
New Test
For Bladder Cancer Will Significantly Improve Quality Of Patient Care
http://mnt.to/l/4dLD
Research
Identifies A Way To Make Cancer Cells More Responsive To Chemotherapy
http://mnt.to/l/4dLz
Inflammation
Associated With Heart Surgery May Be Reduced By Omega-3 Fatty Acids
http://mnt.to/l/4dPZ
Cholesterol-Lowering
Nordic Diet
http://mnt.to/l/4dNR
Some
Patients With Treatment-Resistant Colorectal Cancers May Have A New Option
http://mnt.to/l/4dQL
Immunological
Tests Superior In Colon Cancer Screening
http://mnt.to/l/4dLL
Identification
Of Growth Factor Responsible For Triggering Hair Follicle Generation During Wound Healing
http://mnt.to/l/4dRL
Does
Type 2 Diabetes Really Exist?
http://mnt.to/l/4dQP
Self-Monitoring
Most Effective Way To Lower Blood Pressure
http://mnt.to/l/4dLZ
Overcoming Infections Without Antibiotics
http://mnt.to/l/4dPJ
What
Is Athlete's Foot? What Causes Athlete's Foot?
http://mnt.to/l/4dPx
Improving
Sleep And Promoting Recovery In Patients With Mild TBI Using Bright Light Therapy
http://mnt.to/l/4dQC
Extremely
Low Doses Of Marijuana's Psychoactive Component Protect Brain Before And After Injury
http://mnt.to/l/4dQr
Increased
TV Exposure Associated With Higher Consumption Of Sweetened Beverages Among Children
http://mnt.to/l/4dSG
Vegetarians
Live Longer Than Meat-Eaters
http://mnt.to/l/4dSm
Artificial Sweeteners Affect Metabolism And Insulin Levels
http://mnt.to/l/4dNc
Probiotic
Bacteria Beneficial For Brain Function
http://mnt.to/l/4dN5
Participants
Motivated To Sit Less, Move More, By Pedometer Program
http://mnt.to/l/4dQs
12
Minutes Of Exercise A Week Could Be Enough To Stay Fit
http://mnt.to/l/4dQY
Five Epigenetic
Biomarkers Associated With Better Weight Loss Response
http://mnt.to/l/4dPn
Just 12 Minutes
A Week Of High-Intensity Training Improves Fitness In Inactive Men
http://mnt.to/l/4dNz
Mother's
Weight-Loss Surgery Reduces Obesity Risk For Offspring
http://mnt.to/l/4dM3
Anti-Obesity
Studies Find Sea Anemone Venom-Derived Compound To Be Effective
http://mnt.to/l/4dL7
Vitamin
D Tests And Deficiency: New Patient Resource For GPs
http://mnt.to/l/4dS3
Symptoms
Of Burnout Suffered By Many US Oncologists Despite High Career Satisfaction
http://mnt.to/l/4dRk
UK Doctors
And Nurses That Are Injured While Treating Unconscious Patients Cannot Test Them For HIV Due To Lack Of Legal Protection
http://mnt.to/l/4dQR
Lower Risk Of Cancer For Children Of Long-Lived Parents
http://mnt.to/l/4dMj
Fatigue And Sleep Linked To MLB Performance And Career Longevity
http://mnt.to/l/4dQw
Perception
Of A Women's Sexual Interest And Intent Altered In Sleep Deprived Men
http://mnt.to/l/4dQv
Statin Use May Be Linked To Musculoskeletal Conditions And Injuries
http://mnt.to/l/4dTC
Dementia:
Diagnosis Possible At Ever Earlier Stages And With Ever Greater Precision
http://mnt.to/l/4f2g
Discovery
Reveals How An Important Protein Helps Translate Learning Into Memory
http://mnt.to/l/4dZM
Alzheimer's
Medications Lower Heart Attack And Death Risk
http://mnt.to/l/4dTS
In Highly
Educated Pre-Alzheimer's Patients, PET Finds Increased Cognitive Reserve Levels
http://mnt.to/l/4dT9
Protein Modification
May Help Control Alzheimer's And Epilepsy
http://mnt.to/l/4dT6
Researchers
Closer To A Blood Test For Alzheimer's Disease
http://mnt.to/l/4dSX
Revised
Clinical Practice Guideline On The Treatment Of Osteoarthritis Of The Knee
http://mnt.to/l/4dVK
Breast
Cancer Screening Does Not Reduce Deaths Says Study Of 40 Years Of Mammograms
http://mnt.to/l/4f3M
Doctors
Increasingly Unclog Heart Arteries Via The Wrist
http://mnt.to/l/4f2r
When
Angry, Talk: Describing Emotional Situations Alters Heart Rate, Cardiac Output
http://mnt.to/l/4dVT
New
Treatment For Actinic Keratosis Now Available In The UK
http://mnt.to/l/4dYP
Dapagliflozin
For Diabetes: No Added Benefit Proven
http://mnt.to/l/4dXF
Avandia (Rosiglitazone)
Does Not Raise Heart Attack Risk, Study
http://mnt.to/l/4dZ8
Vascular
Damage Blocked In Diabetes
http://mnt.to/l/4dWW
Diabetes
And Heart Health Matter To Your Brain
http://mnt.to/l/4dVN
Gastric
Bypass Surgery May Help Manage Diabetes Risk Factors
http://mnt.to/l/4dVV
Sleep Apnea
A Greater Risk For Patients With Type 2 Diabetes Or Hypertension
http://mnt.to/l/4dSQ
Change In
Gut Microbiota May Predict Diabetes
http://mnt.to/l/4dSJ
Erectile
Dysfunction In Young Men May Be More Prevalent Than Previously Thought
http://mnt.to/l/4dYx
Erectile
Dysfunction Much More Common Among Young Men Than Previously Thought
http://mnt.to/l/4dZh
Blood
Pressure At Night Is Higher Than Previously Thought
http://mnt.to/l/4dZZ
Frozen
Fruit Blend Linked To Hepatitis A Outbreak
http://mnt.to/l/4dZd
The
Biology Behind Restless Leg Syndrome
http://mnt.to/l/4dY7
Width Of
Blood Vessels Linked To IQ Score
http://mnt.to/l/4dXR
Caution Recommended
When Using Computerized Concussion Test
http://mnt.to/l/4dWR
Changes In
The Aging Brain Affect Hand-Eye Coordination
http://mnt.to/l/4dVJ
Learning
By Our Mistakes
http://mnt.to/l/4dVD
Cognitive
Function, IQ Linked To Blood Vessels In The Eye
http://mnt.to/l/4dT2
Insight Into
Nature Vs. Nurture Offered By Songbird Study
http://mnt.to/l/4dSB
Essential
Fatty Acid Found In Vegetable Oils Does Not Promote Inflammation In Humans
http://mnt.to/l/4dZq
Vegetable
Oils Do Not Cause Inflammation
http://mnt.to/l/4dZF
Vegetarian
Diets Associated With Lower Risk Of Death
http://mnt.to/l/4dVY
Obesity
Linked To Obsessive-Compulsive Behavior Via Brain Circuit
http://mnt.to/l/4f2w
Insulin
Sensitivity In Obese Teens Improved By A Reduction In BMI
http://mnt.to/l/4dVq
Vegetable
Fats Reduce Prostate Cancer Death Risk
http://mnt.to/l/4f2s
Pomegranate,
Green Tea, Turmeric And Broccoli May Help Fight Prostate Cancer
http://mnt.to/l/4dZB
Nine
Hallmarks Of Aging
http://mnt.to/l/4dXV
Screening
For Frailty Could Prevent Deaths
http://mnt.to/l/4dVP
Poor
Sleep May Be Most Harmful To Women With Heart Disease
http://mnt.to/l/4dVS
Smartphones
May Disrupt Your Sleep
http://mnt.to/l/4dTk
Enhancing
Indoor Lighting May Improve Office Workers' Physical Well-Being And Sleep Quality
http://mnt.to/l/4dSw
Musculoskeletal Conditions, Injuries May Be Associated With Statin Use
http://mnt.to/l/4dVX
Stroke
Epidemic: New Therapeutic Strategies
http://mnt.to/l/4f2f
Risk Of Stroke
Can Be Reduced By Minor Changes In Cardiovascular Health
http://mnt.to/l/4dYb
Potential
New Way To Combat Malaria
http://mnt.to/l/4dWD
A Protein Developed To Protect And Restore Nerve Cell Communications
http://mnt.to/l/4f7D
Drugs Currently
Prescribed For Other Indications May Influence The Onset And Progression Of Alzheimer's Disease
http://mnt.to/l/4f6x
New
Development In The Understanding Of Alzheimer's Pathology
http://mnt.to/l/4f3C
Molecular
Mechanisms Underlying Alzheimer's Disease Better Understood
http://mnt.to/l/4f2v
Brain
Development Affected In Male And Female Offspring Of Stressed Male Mice
http://mnt.to/l/4f6p
Workplace
And Financial Stress Lead To Poor Health Choices
http://mnt.to/l/4f5H
Effective
In Juvenile Idiopathic Arthritis
http://mnt.to/l/4f5Q
Body Clocks
Linked To Osteoarthritis
http://mnt.to/l/4f4L
Increased
Muscle Mass In The Elderly Achieved By Dietary Supplement
http://mnt.to/l/4f9q
Bones
Affected By Excessive Salt Consumption
http://mnt.to/l/4f9n
South
Asian Women Have Higher Breast Cancer Risk Than White Women, UK
http://mnt.to/l/4f8g
Is
The Ability To Extinguish Fear Impaired By Antidepressants?
http://mnt.to/l/4f2L
Study
Suggests Association Between Hypoglycemia, Dementia In Older Adults With Diabetes
http://mnt.to/l/4f5t
Short Walks
May Lower Risk Of Type 2 Diabetes In Older People
http://mnt.to/l/4f4j
Vitamin
C Reduces Exercise-Induced Bronchoconstriction (Asthma) Symptoms
http://mnt.to/l/4f8P
In Gout Flare-Ups,
The Big Toe Isn't The Biggest Culprit - Other Joints Tied To Higher Risk
http://mnt.to/l/4f4p
Vitamin D
Can Help Prevent Hypertension
http://mnt.to/l/4f86
Blood Pressure
Is Higher At Night Than Originally Thought
http://mnt.to/l/4f3Z
Link Clarified
Between Hypertension And Vitamin D Deficiency
http://mnt.to/l/4f2B
Eww!
Only 5 Percent Wash Hands Correctly
http://mnt.to/l/4f2J
Cell
Biologists Identify A Memory-Boosting Chemical In Mice
http://mnt.to/l/4f8q
Protein
Aggregation Implicated In Neurodegenerative Diseases Also Critical For Normal Cells
http://mnt.to/l/4f76
Heading The
Ball Frequently In Soccer May Lead To Brain Injury
http://mnt.to/l/4f37
Red
Meat Raises Type 2 Diabetes Risk
http://mnt.to/l/4f99
Gustatory
Sensors Determine Whether Salty Foods Taste Good Or Bad
http://mnt.to/l/4f72
Prunes Benefit
Digestive Health Says European Food Standards Agency
http://mnt.to/l/4f6J
Brain
Inflammation Due To Obesity Compounded By Low Testosterone
http://mnt.to/l/4fby
Lack Of Sleep
May Trigger The 'Munchies' By Raising Levels Of An Appetite Stimulant
http://mnt.to/l/4f9t
Excess Stress
Hormones Found In Obese Men After Eating
http://mnt.to/l/4f9r
Blood Sugar
Control Improved By Weight Loss Drug Plus Diet And Exercise
http://mnt.to/l/4f9k
How Paternal
Diet And Weight May Impact Offspring
http://mnt.to/l/4f8J
Cocoa Powder
Effective In Treating Obesity-Related Inflammation In Mouse Model
http://mnt.to/l/4f6r
The Effectiveness
Of Green Coffee Bean Weight-Loss Supplements Questioned
http://mnt.to/l/4f6j
Lifestyle
Changes Made By Older Patients To Avoid Fractures
http://mnt.to/l/4f8v
Olfactory
Decline In Seniors Can Perturb Diet, Presage Disease And Predict Death
http://mnt.to/l/4f6s
Researchers
Identify Sleep Mechanism That Plays A Role In Emotional Memory
http://mnt.to/l/4f7c
Obstructive
Sleep Apnea Raises Sudden Cardiac Death Risk
http://mnt.to/l/4f44
Binge Drinking
Associated With Insomnia Symptoms In Older Adults
http://mnt.to/l/4f2D
Unwanted Side Effects May Plague Potential
Alzheimer's Disease Drugs Under Development
http://mnt.to/l/4fhm
The
Interaction Of Proteins In The Brain Is A Possible Cause Of Alzheimer's Disease
http://mnt.to/l/4fds
New
Drug Developed That Reverses Loss Of Brain Connections In Alzheimer's
http://mnt.to/l/4f9K
Early
Arthritis Associated With Reduced Consumption Of Alcohol
http://mnt.to/l/4ff6
Findings
Will Help Explain Vitamin D's Role In Seasonal Illnesses
http://mnt.to/l/4fhg
2013 Update
On Diagnosis And Management Of Osteoporosis, Published By Maturitas
http://mnt.to/l/4fdV
How Bone
Adapts To Exercise Likely Affected By Timing Of Calcium And Vitamin D Supplementation
http://mnt.to/l/4fcn
Moderation
Seems To Be Key When It Comes To Eating Fish To Prevent Atrial Fibrillation
http://mnt.to/l/4fjf
Paroxysmal
Atrial Fibrillation Patients Should Be Screened For Depression
http://mnt.to/l/4fhC
Adverse
Cardiovascular Events May Be Predicted By Atherosclerosis In Abdominal Aorta
http://mnt.to/l/4fcq
Heart Attack,
Stroke Risk Increases With Atherosclerosis In Abdominal Aorta
http://mnt.to/l/4fbQ
Screening
Colonoscopy Associated With Increased Survival Duration And Rates For Patients With Colon Cancer
http://mnt.to/l/4fdm
Depression
Treatment Failing Two Thirds Of Patients
http://mnt.to/l/4fgP
Diabetes Lifestyle Intervention Does Not Reduce Heart Attack Or
Stroke Risk
http://mnt.to/l/4fj7
JANUVIA (Sitagliptin)
Compared With Sulfonylurea For Patients With Type 2 Diabetes And Mild Renal Impairment
http://mnt.to/l/4fhz
Eating
More Red Meat Associated With Increased Risk Of Type-2 Diabetes
http://mnt.to/l/4fd4
Early
Diagnosis Of The Metabolic Syndrome Can Trigger Preventive Treatment Sooner, Before Type 2 Diabetes Develops
http://mnt.to/l/4fcm
Comparing
Insulin Degludec And Insulin Glargine
http://mnt.to/l/4fck
Blood
Test Predicts Type 1 Diabetes Risk
http://mnt.to/l/4fdv
Sleep Could
Be Key To Preventing Type 2 Diabetes
http://mnt.to/l/4fc5
Men
Who Can't Produce Sperm Face Increased Cancer Risk, Stanford-Led Study Finds
http://mnt.to/l/4fgW
Low Sperm
Linked To Cancer Risk
http://mnt.to/l/4fh7
Association
Between Childhood Pneumonia And Indoor Environment Factors In Modern Homes
http://mnt.to/l/4fhr
Hand Washing
Averts Petting Farm Illnesses
http://mnt.to/l/4fhY
Low
Doses Of Silver Make Bacteria More Susceptible To Antibiotic Attack
http://mnt.to/l/4ffr
Silver Boosts
Effect Of Antibiotics
http://mnt.to/l/4ffS
Scientists
Discover Key Signaling Pathway That Makes Young Neurons Connect
http://mnt.to/l/4fgV
Study
Validates Maps Of The Brain's Resting State
http://mnt.to/l/4ffb
Scientists
Create A Way To See Structures That Store Memories In A Living Brain
http://mnt.to/l/4ff2
Study Of
Dietary Intervention Examines Proteins In Brain
http://mnt.to/l/4fd8
Does Coffee
Reduce Appetite?
http://mnt.to/l/4fkM
How Safe
Is Splenda (Sucralose)?
http://mnt.to/l/4fkF
Vitamin D
Levels Significantly Increased By Probiotic Lactobacillus Reuteri NCIMB 30242
http://mnt.to/l/4ffN
Don't
Put Your Veggies In Dark Places
http://mnt.to/l/4fh5
New Tool
To Measure Sugar Consumption
http://mnt.to/l/4fcK
SaltSmart
Consortium Endorses Plan To Halve Dietary Salt Consumption In The Americas By 2020
http://mnt.to/l/4fdb
A
High-Fat Diet Impairs Memory And Learning In Adolescent Mice
http://mnt.to/l/4f9h
Causal
Relationship Between Adiposity And Heart Failure, And Elevated Liver Enzymes
http://mnt.to/l/4fkp
Motivating
Patients To Change Lifestyle And Improve Health - Is It Possible?
http://mnt.to/l/4fj3
New Low Cost
Method Of Measuring Pleasure Response To Tasting Food
http://mnt.to/l/4fhZ
CNIO Researchers
Discover A New Gene Involved In Obesity
http://mnt.to/l/4fgg
In Animal
Model, Dietary Fructose Found To Cause Liver Damage
http://mnt.to/l/4ffH
Your
Weight, Eating Behavior, Likely Impacted By What You Believe Causes Obesity
http://mnt.to/l/4fcx
Obesity
Is Now A Disease, American Medical Association Decides
http://mnt.to/l/4fdz
http://mnt.to/l/4f9V
The Importance
Of A Father's Diet Before Conception
http://mnt.to/l/4f9T
Obese Women
Who Skip Breakfast At Greater Risk For Insulin Resistance
http://mnt.to/l/4f9R
Heart Failure
And Hypertension Meds May Help Decrease Obesity
http://mnt.to/l/4f9D
Overweight
Women Who Lose Weight Experience Improved Memory
http://mnt.to/l/4f9s
Study
Reveals That Nearly 7 In 10 Americans Are On Prescription Drugs
http://mnt.to/l/4fff
The
Link Between Circadian Rhythms And Aging
http://mnt.to/l/4fgN
Lifespan
Of Fruit Flies Boosted By Nearly 25 Percent By Herbal Extract
http://mnt.to/l/4fcs
Preventing
Vascular Calcification May Treat One Of The Main Symptoms Of Premature Aging Disease
http://mnt.to/l/4fb4
A Higher Strength Of Cholesterol-Lowering Drugs Did Not
Increase The Risk Of Kidney Injury After Heart Attack
http://mnt.to/l/4ff3
Weight Loss Promoted By Drug Combination In Polycystic Ovary Syndrome
http://mnt.to/l/4fbN
After Uterus
And Ovary Removal, Testosterone Therapy Improves Sexual Function
http://mnt.to/l/4f9Q
